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Leukotriene Receptor Antagonists (LTRAs)

Leukotriene receptor antagonists, called LTRAs for short, are a class of oral medication that is non-steroidal. They may also be referred to as anti-inflammatory bronchoconstriction preventors. LTRAs work by blocking a chemical reaction that can lead to inflammation in the airways. Although not preferred first choice therapy. LTRAs can also be used when an inhaled corticosteroid cannot, or will not, be used.

If you’ve been taking inhaled steroids and your asthma still isn’t well-controlled, your doctor may prescribe LTRAs instead of increasing the dosage of your inhaled steroids.

LTRAs do not contain steroids; they come in pill formats (including chewable tablets or liquid for children) and have few side effects. LTRAs may also be prescribed to treat allergic rhinitis. If there is no improvement in your symptoms after 4 weeks of use, your doctor will change your treatment.

Examples of LTRAs include:

  • Montelukast (sold as Singulair®)
  • Zafirlukast (sold as Accolate®)

The side effects of LTRAs include:

  • Nausea
  • Headache